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Tadalafil kicks in about 30 minutes after you take it, while the maximum potential for an erection is about 2 hours after taking. The crucial part, though, is that it remains active in your body for much longer than Sildenafil – for 24-36 hours. That’s why it has the nickname, the “weekend pill”.This means that 4 hours after you take a dose, your body has cleared half of the dose. In most cases, it takes about 5 half-lives for your body to completely remove a drug from your system. So ...Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone ...

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